Evidence for an endogenous peptide ligand for the phencyclidine receptor.
Peptides 1984 R Quirion, D A DiMaggio, E D French et al.
Porcine brain contained an active factor that competed with [3H]-phencyclidine (PCP) for binding to rat brain membranes. On reverse phase high pressure liquid chromatography, the active material eluted between 38-42% acetonitrile. Gel filtration chromatography of the factor predicted a molecular weight of approximately 3000 daltons. The endogenous substance appeared to be selective for PCP...