Electrophysiological effects of phencyclidine in the medial prefrontal cortex of the rat.
Neuropharmacology September 1987 A Gratton, B J Hoffer, R Freedman
The effects of local applications of phencyclidine (PCP) and dopamine (DA) on neurons of the medial prefrontal cortex were investigated using single unit recording techniques. The activity of the majority of cells in the deeper layers of the medial prefrontal cortex was depressed by both phencyclidine and DA, whereas increases, as well as decreases, in the firing rates were observed in cells...