Effects of route of administration on dextromethorphan pharmacokinetics and behavioral response in the rat.
Journal of Pharmacology and Experimental Therapeutics September 1, 1995 D. Wu, S. Otton, Werner Kalow et al.
One of the potential problems of using dextromethorphan as a neuroprotective or anticonvulsant agent is the phencyclidine-like behavioral effects that have been attributed to its major metabolite dextrorphan. Because previous behavioral studies of dextromethorphan have generally failed to consider metabolic conversion to this metabolite, the present studies were conducted to examine the effects...