Phencyclidine-induced stereotype in rats: effects of methadone, apomorphine, and naloxone.
Psychopharmacology 1981 K Verebey, M J Kogan, S J Mulè
Phencyclidine (PCP) given to male Wistar rats produced hyperactivity and various stereotypic motor behaviors. Methadone, apomorphine, and naloxone were tested for their effects on PCP-induced stereotypy. Methadone (0.5 mg/kg) had no effect on the hyperactivity produced by PCP, but significantly attenuated PCP-induced stereotypy when given both before and after PCP. Low doses of apomorphine were...