Interactions in man of delta-9-tetrahydrocannabinol. II. Cannabinol and cannabidiol.
Clinical pharmacology and therapeutics July 1975 L E Hollister, H Gillespie
Oral doses of delta-9-tetrahydrocannabinol (THC) 20 mg, combined with placebo or with 40 mg dses of cannabinol (CBN) and cannabidiol (CBD), were given to volunteers. The combination of THC with CBN produced no detectable changes in the quality, intensity, or duration of the effects of THC alone. The THC-CBD combination tended to delay onset and prolong effects of THC, while making them somewhat...