Contrasting Neurochemical Interactions of Tiletamine, a Potent Phencyclidine (PCP) Receptor Ligand, with the N ‐Methyl‐D‐Aspartate‐Coupled and ‐Uncoupled PCP Recognition Sites
Journal of Neurochemistry March 1, 1991 Tadimeti S. Rao, Patricia C. Contreras, Julie A. Cler et al. 19 citations
Neurochemical interactions of tiletamine, a potent phencyclidine (PCP) receptor ligand, with the N-methyl-D-aspartate (NMDA)-coupled and -uncoupled PCP recognition sites were examined. Tiletamine potently displaced the binding of [3H]1-(2-thienyl)cyclohexylpiperidine with an IC50 of 79 nM without affecting sigma-, glycine, glutamate, kainate, quisqualate, or dopamine (DA) receptors. Like other...