Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
Journal of Pharmacology and Experimental Therapeutics March 1, 1992 I. Øye, O. Paulsen, A. Maurset
The chiral forms of ketamine were applied as probes for N-methyl-D-aspartate receptor-mediated neurotransmission in humans. Both enantiomers, in clinically relevant concentrations, displaced [3H]dizocilpine (MK 801) from specific binding sites (phencyclidine sites) in membrane fractions of brain homogenates. (S)-Ketamine was at least 4 times as potent as (R)-ketamine in this respect. In healthy...