The effect of MK-801 and other antagonists of NMDA-type glutamate receptors on brain-stimulation reward.
Psychopharmacology 1989 L J Herberg, I C Rose
MK-801 is a ligand at phencyclidine recognition sites associated with NMDA-coupled cation channels, where it acts as a potent noncompetitive antagonist of central glutamate/aspartate (NMDA-type) receptors. Low doses (10-100 micrograms/kg IP) produced a dose-related and prolonged (greater than 1 h) enhancement of variable-interval self-stimulation responding. Higher doses (300 micrograms/kg)...