Cross-tolerance studies of serotonin receptors involved in behavioral effects of LSD in rats.
Psychopharmacology January 1994 K M Krebs, M A Geyer
Like hallucinogenic 5-HT2 agonists, LSD (d-lysergic acid diethylamide) produces characteristic decreases in locomotor activity and investigatory behaviors of rats tested in a novel environment. Because LSD is an agonist at both 5-HT1A and 5-HT2 receptors, however, the respective influences of these different receptors in the behavioral effects of LSD remain unclear. In particular, the paucity...