The effects of dizocilpine and buprenorphine pretreatment on behavior reinforced by orally delivered phencyclidine (PCP) and saccharin, and on PCP withdrawal-induced disruptions in food-maintained responding were examined. Sixteen male rhesus monkeys were used in six different experimental protocols. Two groups of monkeys (N = 4-5) self-administered PCP (0.25 mg/ml) and water under concurrent...
Six monkeys were trained to self-administer orally delivered phencyclidine (0.25 mg/ml) under a fixed-ratio 16 (FR-16) schedule. Water was concurrently available under an FF-16 schedule. During initial phencyclidine training, three monkeys were allowed free access to food (food satiation) and three were maintained at 85% of their free-feeding body weights (food deprivation). At the end of the...