Effects of self-administered phencyclidine on regional uptake of 2-deoxy-D-[1-14C]glucose in brain.
Neuropharmacology June 1989 A D Weissman, K L Marquis, J E Moreton et al.
Phencyclidine profoundly alters cerebral metabolism in the rat. This study explored whether cerebral metabolic effects of phencyclidine differed when the drug was self-administered by trained rats, compared with when it was given acutely to naive rats. The regional cerebral uptake of 2-deoxy-D-[1-(D14C] glucose (DG) was examined following two injections of phencyclidine (0.5 mg/kg/injection,...