The effect of ketamine on mitochondrial bioenergetics, viability, and function: A systematic review.
Journal of psychopharmacology (Oxford, England) September 7, 2026 Sabrina Wong, Gia Han Le, Simryn Selby et al.
Extant literature indicates mitochondrial dysfunction may contribute to the pathophysiology of depressive disorders. Preclinical data indicate that anesthetic doses of ketamine are associated with deficits in mitochondrial viability and function. Ketamine and esketamine have demonstrated rapid antidepressant effects in persons with difficult-to-treat depressive disorders. Herein, we aim to...