Ketamine induced gut microbiota dysbiosis and barrier and hippocampal dysfunction in rats.
iScience November 15, 2024 Lei Xie, Zelin Zhuang, Baowen Guo et al. 5 citations
The microbiota-gut-brain axis (MGBA) plays a pivotal role in drug addiction. However, the pathophysiological mechanism of MGBA in ketamine addiction remains elusive. The present study investigated the ketamine-induced gut microbiota disorders, intestinal barrier dysfunction, and the alterations in brain function, using a conditioned place preference (CPP) model of ketamine addiction in rats....
DOI: 10.1016/j.isci.2024.111089 (opens in new tab)
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Ketamine
Drugs
Microbiome
Physiology
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