Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats.
Psychopharmacology January 2007 Q David Walker, Christina N Williams, Rakesh P Jotwani et al.
3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") use has been associated with acute toxicities and persistent depletion of the neurotransmitter serotonin (5-HT). This study investigates whether sex differences in the acute and long-term effects of MDMA exist. Male and female rats received saline or 15 mg/kg MDMA, ip, bid for 4 days. Temperature was monitored on days 1 and 4. Locomotor...