Reduced efficacy of fluoxetine following MDMA ("Ecstasy")-induced serotonin loss in rats.
Progress in neuro-psychopharmacology & biological psychiatry December 12, 2008 Sarah Durkin, Alison Prendergast, Andrew Harkin
Long-term serotonin (5-HT) neuronal loss is currently a major cause of concern associated with recreational use of the substituted amphetamine 3,4 methylenedioxymethamphetamine (MDMA; "Ecstasy"). Such loss may be problematic considering that psychiatric disorders such as depression and anxiety and responses to first line treatments for these disorders are associated with 5-HT. In this study the...