Effect of 5-HT depletion by MDMA on hyperthermia and Arc mRNA induction in rat brain.
Psychopharmacology May 2004 Thomas J R Beveridge, Annis O Mechan, Marie Sprakes et al.
3,4-Methylenedioxymethamphetamine (MDMA) administration to rats produces an acute hyperthermic response and induces localised neuronal activation, which can be visualised via expression of immediate-early genes. The pharmacological and anatomical basis of these effects are unclear. At high doses, MDMA also causes selective neurotoxicity at serotonergic nerve terminals. We investigated the...