Key Points Question Are recent cannabis use and lifetime cannabis use associated with differences in brain function during cognitive tasks? Findings In this cross-sectional study of 1003 young adults, heavy lifetime cannabis use was associated with lower brain activation during a working memory task; this association remained after removing individuals with recent cannabis use. These results...
PsychopharmacologyJuly 2011Jody Tanabe, Eric Nyberg, Laura F Martin et al.
The default mode network (DMN), one of several resting-state networks (RSN) in the brain, is thought to be involved in self-referential thought, awareness, and episodic memories. Nicotine improves cognitive performance, in part by improving attention. Nicotinic agonists have been shown to decrease activity in regions within DMN and increase activity in regions involved in visual attention...