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S. McLean

2 papers in the library · publishing 2010-2022

Papers

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Persistent Dissociation and its Neural Correlates Uniquely Predict Worse Outcomes after Trauma Exposure

American Journal of Psychiatry June 22, 2022 Lauren A M Lebois, N. Harnett, S. V. van Rooij et al.

Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma is inconsistent. Determining whether trauma-related dissociation is uniquely predictive of later outcomes would enable early identification of at-risk trauma populations. We completed the largest...

Phencyclidine (PCP)-Induced Disruption in Cognitive Performance is Gender-Specific and Associated with a Reduction in Brain-Derived Neurotrophic Factor (BDNF) in Specific Regions of the Female Rat Brain

Journal of Molecular Neuroscience September 18, 2010 Shikha Snigdha, Joanna C. Neill, S. McLean et al.

Phencyclidine (PCP), used to mimic certain aspects of schizophrenia, induces sexually dimorphic, cognitive deficits in rats. In this study, the effects of sub-chronic PCP on expression of brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of schizophrenia, have been evaluated in male and female rats. Male and female hooded-Lister rats received vehicle...