Archana Mishra

2 papers in the library · 5 citations · publishing 2011-2024

Papers

Early augmentation therapy with dextromethorphan in mild to moderate major depressive disorder: A group sequential, response adaptive randomized controlled trial.

Psychiatry Research December 1, 2024 Shampa Maji, Archana Mishra, Debadatta Mohapatra et al. 5 citations

Adding 30 mg of dextromethorphan daily to standard SSRI treatment for eight weeks led to significantly greater reductions in depression severity, higher response and remission rates, and better clinical global improvement in patients with mild to moderate major depressive disorder, compared to adding a placebo. The combination was well-tolerated, with adverse events comparable between groups. No significant difference in serum BDNF levels was observed. These results suggest that early augmentation of SSRIs with dextromethorphan may improve clinical outcomes.

DOI: 10.1016/j.psychres.2024.116257 Full text Major depressive disorder Adjunct therapy Dextromethorphan Remission rate +6

Isolated nocturnal auditory hallucinations: a case report.

General Hospital Psychiatry January 1, 2011 Biswa Ranjan Mishra, Sukanto Sarkar, Sayali Mishra et al.

Sleep-related hallucinations that occur when falling asleep or waking up are usually brief and happen in healthy people. In rare cases, they become severe and troubling, linked to conditions such as narcolepsy. This case report describes a person who had prominent auditory hallucinations upon waking that gradually became constant and distressing, resembling hallucinations seen in schizophrenia. These hallucinations improved with a low dose of the antipsychotic medication olanzapine.

DOI: 10.1016/j.genhosppsych.2011.04.008 Full text