The present study examined delta 9-tetrahydrocannabinol (THC)-induced alterations in monoamine transmission in the rat forebrain as well as the effects of the enantiomers of 3-amino-1-hydroxypyrrolid-2-one (HA966) on the monoamine response to THC. Activation of dopamine (DA) and norepinephrine (NE) but not serotonin (5-HT) turnover in the prefrontal cortex (PFC) was observed after THC (5 mg/kg...
Whether or not drug use can cause a chronic psychotic disorder that is clinically similar to schizophrenia and related disorders is an important question. In this review, the authors attempt to determine whether there is enough evidence in the literature to support the notion that illicit drug use can cause chronic psychotic disorders. They conclude the literature strongly suggests that a...