Selective phosphodiesterase inhibitors improve performance on the ED/ID cognitive task in rats.
Neuropharmacology March 2012 Joshua S Rodefer, Samantha K Saland, Samuel J Eckrich
A number of selective phosphodiesterase (PDE) inhibitors have been demonstrated to improve learning in several rodent models of cognition. Given that schizophrenia is associated with impairments in frontal lobe-dependent cognitive functions (e.g., working memory and cognitive flexibility), we examined whether PDE inhibitors would attenuate cognitive deficits associated with schizophrenia....