Family History of Alcohol Dependence and Initial Antidepressant Response to an NMDA Antagonist
Biological Psychiatry November 8, 2008 Laura E. Phelps, Nancy E. Brutsché, J. Moral et al.
Background A high rate of comorbidity exists between mood disorders and alcohol dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently described rapid-onset antidepressant effect, and ethanol are N-methyl-D-aspartate (NMDA) receptor antagonists. Previous investigations of healthy individuals with a family history of alcohol-dependence have found that these individuals...