Hallucinatory and rewarding effect of salvinorin A in zebrafish: kappa-opioid and CB1-cannabinoid receptor involvement.
Psychopharmacology March 2007 Daniela Braida, Valeria Limonta, Simona Pegorini et al.
The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. Swimming activity was determined in a squared observational chamber after an i.m. treatment of...