New ultrasensitive detection technologies and techniques for use in microdosing studies.
Bioanalysis June 11, 2009 G. Lappin, C. Wagner, O. Langer et al.
In a microdosing study, subpharmacologically active doses of drug are given to human volunteers at an early stage of development in order to obtain preliminary pharmacokinetic data. The very low doses of drug administered (≤100 µg) consequently lead to very low concentrations of drug appearing in the body and therefore highly sensitive analytical techniques are required. There are three such...