Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models.
Neuroscience June 30, 2009 E Engin, D Treit, C T Dickson
Ketamine, a dissociative anesthetic agent, appears to have rapid antidepressant effects at sub-anesthetic doses in clinically depressed patients. Although promising, these results need to be replicated in double-blind placebo-controlled studies, a strategy thwarted by the psychoactive effects of ketamine, which are obvious to both patients and clinicians. Alternatively, demonstrations of the...