The use of a series of ketamine infusions in two patients with treatment-resistant depression.
The Journal of neuropsychiatry and clinical neurosciences 2010 Michael Messer, Irina V Haller, Pamela Larson et al.
Treatment-resistant depression often leads to increased morbidity and disability. The authors report the use of ketamine, a selective N-methyl-D-aspartate (NMDA) receptor antagonist, in two patients with treatment-resistant depression. Multiple ketamine treatments may provide an effective rapid antidepressant effect with prolonged benefit.