Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine.
Clinical pharmacology and therapeutics August 2011 M A Peltoniemi, T I Saari, N M Hagelberg et al.
This study examined drug-drug interactions of oral S-ketamine with the cytochrome P450 (CYP) 2B6 inhibitor ticlopidine and the CYP3A inhibitor itraconazole. In this randomized, blinded, crossover study, 11 healthy volunteers ingested 0.2 mg/kg S-ketamine after pretreatments with oral ticlopidine (250 mg twice daily), itraconazole (200 mg once daily), or placebo in 6-day treatment periods at...