Ketamine disrupts θ modulation of γ in a computer model of hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience August 10, 2011 Samuel A Neymotin, Maciej T Lazarewicz, Mohamed Sherif et al.
Abnormalities in oscillations have been suggested to play a role in schizophrenia. We studied theta-modulated gamma oscillations in a computer model of hippocampal CA3 in vivo with and without simulated application of ketamine, an NMDA receptor antagonist and psychotomimetic. Networks of 1200 multicompartment neurons [pyramidal, basket, and oriens-lacunosum moleculare (OLM) cells] generated...