Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges.
Neuroscience March 27, 2008 M H Baumann, R D Clark, F H Franken et al.
3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) stimulates the transporter-mediated release of monoamines, including 5-HT. High-dose exposure to MDMA causes persistent 5-HT deficits (e.g. depletion of brain 5-HT) in animals, yet the functional and clinical relevance of such deficits are poorly defined. Here we examine functional consequences of MDMA-induced 5-HT depletions in rats. Male...