Decoupling of motor cortex to movement in Parkinson's dyskinesia rescued by sub-anaesthetic ketamine.
Brain June 3, 2025 Abhilasha Vishwanath, Mitchell J Bartlett, Torsten Falk et al. 8 citations
Gamma-band and single-unit neural activity in primary motor cortex are involved in the control of movement. This activity is disrupted in Parkinson's disease (PD) and levodopa-induced dyskinesia (LID), a debilitating consequence of dopamine replacement therapy for PD. Physiological features of LID include pathological narrowband gamma oscillations, finely tuned gamma and altered primary motor...
DOI: 10.1093/brain/awae386 (opens in new tab)
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In vivo electrophysiology
6-hydroxydopamine hemi-lesioned model
Cell types
Inertial speed
+4