Rats preexposed to MDMA display attenuated responses to its aversive effects in the absence of persistent monoamine depletions.
Psychopharmacology August 2011 Daniel L Albaugh, Jennifer A Rinker, Michael H Baumann et al.
The abuse potential of a given drug may be mediated by both its rewarding and aversive effects, the latter of which are often far less characterized. Using the conditioned taste-aversion (CTA) preparation, the present experiments examined changes in the aversive effects of the commonly used recreational drug MDMA following repeated drug exposures. Experiment 1 used three varying doses of MDMA...