Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice.
Pharmacology, biochemistry, and behavior January 2008 C M Krall, J B Richards, R A Rabin et al.
Based upon extensive studies in the rat, it has been suggested that stimulus control by LSD is mediated by 5-HT2A receptors, with serotonergic receptors of the 5-HT1A and 5-HT2C subtypes playing modulatory roles. In genetically modified mice lacking the serotonin transporter (SERT), 5-HT2A receptor density is decreased and, at a functional level, the head-twitch response following the...