K L Leenders

2 papers in the library · publishing 1997-1999

Papers

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5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man--a PET study with [11C]raclopride.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology May 1999 F X Vollenweider, P Vontobel, D Hell et al.

The modulating effects of serotonin on dopamine neurotransmission are not well understood, particularly in acute psychotic states. Positron emission tomography was used to examine the effect of psilocybin on the in vivo binding of [11C]raclopride to D2-dopamine receptors in the striatum in healthy volunteers after placebo and a psychotomimetic dose of psilocybin (n = 7). Psilocybin is a potent...

DOI: 10.1016/s0893-133x(98)00108-0 Full text

Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology May 1997 F X Vollenweider, K L Leenders, C Scharfetter et al.

The effects of the indolehallucinogen psilocybin, a mixed 5-HT2 and 5-HT1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15- or 20-mg dose of psilocybin. Psychotomimetic doses of psilocybin were found to produce a global increase in cerebral metabolic rate of glucose (CMRglu) with...

DOI: 10.1016/s0893-133x(96)00246-1 Full text