Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.
Drug metabolism and disposition: the biological fate of chemicals March 2010 Nenad Manevski, Mika Kurkela, Camilla Höglund et al.
We have examined the glucuronidation of psilocin, a hallucinogenic indole alkaloid, by the 19 recombinant human UDP-glucuronosyltransferases (UGTs) of subfamilies 1A, 2A, and 2B. The glucuronidation of 4-hydroxyindole, a related indole that lacks the N,N-dimethylaminoethyl side chain, was studied as well. UGT1A10 exhibited the highest psilocin glucuronidation activity, whereas the activities of...