P S Branco

2 papers in the library · publishing 2007-2017

Papers

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Hyperthermia Severely Affects the Vascular Effects of MDMA and Metabolites in the Human Internal Mammary Artery In Vitro.

Cardiovascular toxicology October 2017 D A Fonseca, A F Guerra, F Carvalho et al.

3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") is a recreational drug used worldwide for its distinctive psychotropic effects. Although important cardiovascular effects, such as increased blood pressure and heart rate, have also been described, the vascular effects of MDMA and metabolites and their correlation with hyperthermia (major side effect of MDMA) are not yet fully understood and...

DOI: 10.1007/s12012-017-9398-y Full text MDMA 3,4-methylenedioxymethamphetamine 5-hydroxytryptamine Hyperthermia +1

Neurotoxicity mechanisms of thioether ecstasy metabolites.

Neuroscience June 8, 2007 J P Capela, Carla Macedo, P S Branco et al.

3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy"), is a widely abused, psychoactive recreational drug that is known to induce neurotoxic effects. Human and rat hepatic metabolism of MDMA involves N-demethylation to 3,4-methylenedioxyamphetamine (MDA), which is also a drug of abuse. MDMA and MDA are O-demethylenated to N-methyl-alpha-methyldopamine (N-Me-alpha-MeDA) and alpha-methyldopamine...

DOI: 10.1016/j.neuroscience.2007.03.028 Full text