5-HT1B receptor activation produces rapid antidepressant-like effects in rodents.
Pharmacology, biochemistry, and behavior February 1, 2025 Erin A Clark, Lien Wang, Taleen Hanania et al. 5 citations
Ketamine is noted for its rapid onset antidepressant response and effectiveness in patients with treatment resistant depression. While most research has focused on glutamatergic mechanisms, recent studies show that antidepressant-like effects in rodents are dependent upon the serotonergic (5-HT) system and suggest a potential contribution of the 5-HT1B receptor. In this study we utilized...