Mild cognitive impairment (MCI) is regarded a potential early stage of Alzheimer’s disease (AD) and associated with a significantly increased risk of progression to AD. This study aims to evaluate whole-brain static functional connectivity (SFC) disruptions with the default mode network (DMN) seed points in patients with MCI by resting-state functional magnetic resonance imaging (rs-fMRI), and...
RATIONALE AND OBJECTIVES Alzheimer's disease (AD) is the most common pathogenesis of dementia, and mild cognitive impairment (MCI) is considered as the intermediate stage from normal elderly to AD. Early detection of MCI is an essential step for the timely intervention of AD to slow the progression of this disease. Different form previous studies in the whole-brain spontaneous activities, this...