Protracted encephalopathy and subacute combined degeneration associated with chronic nitrous oxide use: a case report
Frontiers in Psychiatry May 15, 2026 Kaevon Brasfield, Eugene Pahk, Conrado Sevilla
Nitrous oxide is a dissociative hallucinogen that is increasingly used recreationally, in part due to its widespread availability. Its use is known to cause subacute combined degeneration via inactivation of vitamin B12; it may also result in acute delirium and chronic progressive encephalopathy. Though current practice guidelines call for treatment of neurological sequelae of nitrous oxide use...