AMCP Market Insights: Optimizing managed care approaches to treatment-resistant depression.
Journal of managed care & specialty pharmacy September 2026 Bridget Flavin, Gary Small, Charles Dragovich et al.
Treatment-resistant depression (TRD) is a subset of major depressive disorder (MDD) most commonly defined as failure to respond to 2 or more antidepressant regimens despite adequate dose, duration, and adherence to treatment. The burden of TRD impacts individuals, families, and society, with outcomes such as decreased health-related quality of life and increased health care utilization and...