Differential effects of psilocybin derivatives on fentanyl-induced conditioned place preference in male and female mice.
Journal of psychopharmacology (Oxford, England) August 30, 2026 Tiffini N Lovell, Peter B James, Skylar L Hodgins et al.
Fentanyl is the leading cause of fatal overdoses worldwide, and repeated use may lead to substance use disorder (SUD). In SUD, drug-associated contexts can trigger reward-related behavior even in the absence of the drug. Psychedelic compounds may weaken context-drug associations, reducing reward-related behavior to fentanyl. We evaluated the effects of the psychedelic psilocin and its...