In vivo evaluation of synthetic cannabinoid JWH-018 derivatives as potential new psychoactive substances
Scientific Reports May 11, 2026 Salman Khan, Minseo Baek, Jeong-Hoon Jang et al.
Synthetic cannabinoid receptor agonists constitute a prominent class of new psychoactive substances (NPS), in which minor structural modifications can markedly influence in vivo pharmacological outcomes. In this study, methoxy-substituted derivatives of JWH-018 were synthesized to examine the effect of substitution position on behavioral activity. JWH-018–5-OMe and JWH-018–6-OMe were evaluated...