What is the current status of research for esketamine in the treatment of bipolar depression? A literature review
European Psychiatry June 1, 2026 O. Vasiliu, D. G. Vasiliu
Introduction Hopes related to esketamine have been raised by its approval for treatment-resistant major depression (TRD) in the sense that this antidepressant, with a novel mechanism of action, will be useful for patients with bipolar depression (BD), too. The need to find more evidence-based pharmacological approaches to both TRD and BD is acute due to the high rates of partial response or...