Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression.
Pharmacological Research 2025 Nicole R Silva, Shokouh Arjmand, Luana B Domingos et al. 6 citations
Ketamine (KET) is recognized as rapid-acting antidepressant, but its mechanisms of action remain elusive. Considering the role of endocannabinoids (eCB) in stress and depression, we investigated if S-KET antidepressant effects involve the regulation of the eCB system using an established rat model of depression based on selective breeding: the Flinders Sensitive Line (FSL) and their controls,...