Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neurons
Carlo Sala, Jessica Pagano, Eleonora Mangano et al. preprint
Abstract Major depressive disorder (MDD) is a leading cause of global disability, and a substantial proportion of patients develop treatment-resistant depression (TRD), highlighting the urgent need for mechanistically novel and fast-acting antidepressants. Ketamine has emerged as a paradigm-shifting therapy due to its rapid and robust antidepressant effects, yet its molecular mechanisms in...