1080 Psilocybin Elicits Non-Linear Night to Night Changes in Sleep Spectral Power
SLEEPJ May 1, 2026 Matthew J. Reid, E. Weisman, Luis Luna Martinez et al.
Despite evidence of an acute effect of psilocybin on sleep physiology, its enduring effects beyond the period of acute administration and active metabolism remain unexplored. Within a clinical trial of psilocybin-assisted therapy for alcohol use disorder comorbid with major depressive disorder, we monitored sleep for ten continuous nights (3 pre-dose | 7 post-dose) in participants (N=22)...