Ultrasonic potentiation of ketamine neuromodulation.
bioRxiv : the preprint server for biology August 4, 2026 Kanchan Sinha Roy, Payton Martinez, Sedona N Ewbank et al. preprint
The psychiatric utility of ketamine is limited by its dissociative and systemic side effects. Recently, to enable precision ketamine pharmacotherapy, we introduced SonoKet, ketamine-loaded acoustically activatable liposomes that enable focused ultrasound (FUS)-targeted ketamine delivery to millimeter-sized brain regions. In initial studies, we observed that SonoKet uncaging targeted ketamine to...