The application of esketamine in cancer-related depressive states: attention from mechanisms to clinical translation
Frontiers in Psychiatry July 30, 2026 Liangju Chen, Yonghua Chen, Ying Zhao et al.
Objectives: This article reviews the clinical status and treatment challenges of cancer-related depressive states, clarifies the mechanism of action of esketamine-a novel rapid-acting antidepressant-compares its efficacy with traditional drugs, evaluates safety and tolerability, and summarizes clinical evidence to support clinical practice and research. Methods: By searching databases such as...