Long- term administration of low doses of psilocybin causes epigenetic changes in the rat medial prefrontal cortex
Psychopharmacology July 28, 2026 Agnieszka Wawrzczak-Bargieła, Małgorzata Jelonek-Kozioł, Weronika Kumorek et al.
RATIONALE: Psilocybin (PSI) microdosing, defined as a repeated administration of sub-perceptual doses, has gained increasing attention as a potential therapeutic strategy for affective and anxiety disorders. However, some molecular mechanisms, particularly regarding epigenetic regulation in the medial prefrontal cortex (mPFC), remain poorly understood. OBJECTIVES: Therefore, the present study...