Identifying factors that contribute to the behavioral effects of psilocybin in preclinical mouse models
Sixtine Fleury, Luke J. Chang, Katherine M. Nautiyal
ABSTRACT Psychedelic drugs offer a potentially promising avenue for novel therapeutics for the treatment of psychiatric conditions, including for mood and anxiety disorders. Emerging clinical studies have prompted increased preclinical research into mechanisms of action. However, post-acute behavioral outcomes in rodents remain inconsistent and difficult to reproduce across laboratories. To...