Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote behavioral perseverance.
Neuron February 5, 2025 Marc Duque, Alex B. Chen, Eric Hsu et al. 27 citations
Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit...